Most Common Types Of Cancer Found In Li-Fraumeni Syndrome

Li-Fraumeni syndrome is a disorder that causes an individual's risk of developing certain types of cancers to be significantly greater than the general population. Specific mutations an affected individual inherits from their parents are implicated in the development of Li-Fraumeni syndrome. The mutations that cause Li-Fraumeni syndrome occur on the TP53 gene and CHEK2, which are both tumor suppressor genes. The average chance of a Li-Fraumeni syndrome patient to develop any form of cancer is ninety percent. Around half of all cancers that develop in these patients are diagnosed before the third decade of life. There is no cure for Li-Fraumeni syndrome and no symptoms aside from the increased development of cancer. Treatment is based around diligent screening protocols that increase the chances of early detection of cancer.