Comprehensive Guide To The Symptoms Of POEMS Syndrome

Endocrinopathy

Endocrinopathy or abnormalities of the endocrine system and its function may occur in individuals with POEMS syndrome. Gonadal failure is a condition where the ovaries in females and testes in males do not function properly, and around seventy percent of individuals with POEMS syndrome develop it. The results of this include amenorrhea or stoppage of the menstrual cycle, gynecomastia or abnormal enlargement of the breasts, and impotence. Around half of individuals with POEMS syndrome will develop an endocrine disease called diabetes mellitus, which is a disease where the beta cells of the pancreas do not secrete the insulin needed to mediate glucose in the blood. Additionally, many individuals with POEMS syndrome will experience issues with the functioning of the thyroid gland such as hyperthyroidism or hypothyroidism. Furthermore, POEMS syndrome may cause problems with the functioning of the adrenal glands, which are responsible for the release of aldosterone and cortisol.

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