Signs Of Paroxysmal Nocturnal Hemoglobinuria

Fatigue And Weakness

Without red blood cells available to help carry oxygen to parts of your body that need it, you can start to feel out of breath a lot. Paroxysmal nocturnal hemoglobinuria can also cause pulmonary hypertension, which means a higher blood pressure in the area of your lungs. These two things combined can lead to fatigue and weakness.

You may also experience these symptoms due to a low nitric oxide level. This compound is normally available to help keep the tone of membranes and prevent activation of the platelets or blood clotting factors. Hemoglobin, a product of broken down red blood cells, binds very easily to the nitric oxide and lowers the overall concentration of it in your system. The mechanisms in place to limit hemoglobin and stop this process from happening are overwhelmed by the large amounts of red blood cells being destroyed. The low nitric oxide level leads to exhaustion and blood clotting.

Speaking of blood clotting, continue reading to learn more about it as a symptom.