What Increases The Risk Of Chondrosarcoma?
Wilms' Tumor
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Wilms' tumor or nephroblastoma is a type of cancer where a tumor starts growing in one or both kidneys. It most often affects young children. The cause of Wilms' tumor is unclear, but in rare cases, genetics and the presence of other conditions are known to play a role. Most children with this condition are diagnosed between three and four years old. A child's Wilms' tumor can spread to other regions of the body when it goes untreated, and affected children are at a higher risk of developing chondrosarcoma. The cancerous cells in the kidney of Wilms' tumor patients have the opportunity to come in contact with certain cells of the bones. The bones have a naturally enticing microenvironment for malignant cells due to the normal bone remodeling process. During bone remodeling, the body breaks down old unhealthy bone and then creates new healthy bone tissue in its place. Part of this process includes the release of certain hormones when old bone is broken down. These hormones initiate the process of new cell growth. The interaction between such hormones in the bone remodeling process and the malignant cells floating around from a child's Wilms' tumor can initiate the process of cancerous cell growth in the cells that produce cartilage or chondrosarcoma.