Causes Of Adrenal Insufficiency

Fungal Infection

In many ways, fungal infections of the adrenal glands are similar to other bacterial or viral infections. The most common form of adrenal fungal affliction, Paracoccidioides brasiliensis, may affect gland function at differing rates based on the health and immune response of the individual infected. Specifically, this dimorphic fungus may invade the adrenal tissue directly or may be introduced into the glands through biochemical modulators or other secondary mediators in the bloodstream. In either case, the fungus can cause the production of endotoxins, which may lead to damage and hemorrhaging within the tissue. This hemorrhaging, in turn, may lead to a condition known as Waterhouse-Friderichsen syndrome, a condition characterized by shock and acute adrenal insufficiency.

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