Common Causes Of Alagille Syndrome

Notch Signaling Pathway

The Notch signaling pathway is the system in which cells communicate with each other during development. This occurs in almost all multicellular organisms. Notch receptors are present on all cells, and the transfer of information is dependent upon calcium. A ligand from one cell connects to the Jagged-1 protein on another cell or the Notch receptor. There is a single pass of information through the protein into the cell, where a part of the protein cuts off and takes the information to the cell’s nucleus., which determines and regulates what the cell will become. When mutations occur, the cells develop abnormally causing the symptoms associated with Alagille syndrome.

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