Common Symptoms Of Uremia

Abnormal Bleeding

An individual who has uremia may experience abnormal bleeding as a symptom manifestation of their condition. Abnormal bleeding in uremia can present as easy bruising of the skin, oral bleeding, nasal bleeding, blood in the urine, blood in the stool, or blood in coughed-up sputum or mucus. An affected individual may also lose an abnormally large quantity of blood when undergoing invasive procedures or when they have become injured. This type of bleeding occurs when the toxins that build up in the blood of uremic patients render a large number of their platelets non-functional. The exact mechanism of the action is not entirely understood. However, other factors that can contribute to this symptom are anemia and an abnormal reaction between the platelets and endothelial tissues. Toxins in the blood due to uremia can cause problems with the normal process of platelet adhesion. There is also a defect that can be seen in some patients where the platelets are not secreted properly. It is estimated between twenty-four and fifty-five percent of patients affected by uremia precipitated from their end-stage renal disease are impacted by bleeding complications.

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