Common Symptoms Of Uremia

Pericarditis

An individual affected by uremia may experience pericarditis. The fibroelastic sac that surrounds the heart is called the pericardium. There is usually between fifteen and fifty milliliters of fluid that stays between the pericardium's two layers to lubricate them. Pericarditis occurs when this sac around the heart becomes inflamed and swollen. The uremic toxins in the blood of affected individuals are known to produce a sharp increase in the yield of nitrogenous waste substances. These waste substances can have a pro-inflammatory effect that can contribute to the development of pericarditis. This inflammatory reaction includes the secretion of the inflammatory markers interleukin 6, interleukin 1, and tumor necrosis factor. This process results in adhesions, deposits of fibrous tissues, and severe inflammation that all cause the pericardium to become damaged. Additionally, pericardial effusion or a buildup of fluid in the pericardium may occur due to a hemorrhage associated with the impaired platelet function in a patient. This disposition of fluid or blood can cause further damage to the pericardium, exacerbating the inflammatory responses that cause pericarditis.

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