Signs Of Hypophosphatasia

Short Limbs

Short limbs are a direct result of weakened bones and stunted bone growth. Bones require mineralization to increase in size and remain strong. Without it, bones are unable to grow to their full potential. Because the bones tend to be weaker with hypophosphatasia, fractures are more common. This also hinders bone growth because injured bone is unable to repair itself properly without mineralization. This disease is inherited in both autosomal recessive and autosomal dominant fashion. Therefore, the shorter appendages can be detected on a sonogram before birth. Should this occur, enzyme therapy can be started to lessen the effects of hypophosphatasia.

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