Indicators Of Metachromatic Leukodystrophy

Developmental Delays

Developmental delays, which are common in metachromatic leukodystrophy, are typically noticed after problems with motor skills begin. In the late infantile form of this condition, speech and overall cognition are both impacted. Patients with the juvenile form may experience cognitive symptoms before motor skills are affected. The first sign is normally a period of unexplained behavioral outbursts, and the patient then has a complete lack of memory about these and other recent events. Social skills will decline, and patients will lose the ability to follow simple directions and sequences. Speech becomes slurred, and the patient may begin talking less than usual. These developmental delays become progressively worse, and they cannot be treated with therapies. As the disease advances, patients lose the intellectual skills they previously had.

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