What Increases The Risk Of Calciphylaxis?

Uremia

Uremia is a medical condition that occurs when the kidneys fail to filter the blood of wastes that would normally be eliminated through the urine. The translation of this term is 'urine within the blood.' Uremia patients will typically have increased levels of creatine, proteins, and other substances within their blood. Having this condition can significantly raise the risk of developing calciphylaxis. The way this happens is uremic toxins build up in the blood, prompting an increase of excessive reactive oxygen species (ROS) in the blood. Elevated levels of ROS in the blood vessels can result in endovascular fibrosis or the hardening and scarring of the blood vessel interior due to an overgrowth of cells. Uremia also causes a significant decrease of factors in the blood that inhibit the calcification of proteins to the inner blood vessel walls. In addition, uremia promotes the development of calciphylaxis because the excessive ROS in the blood induces an inflammatory response by the immune system. This inflammatory response has detrimental effects on the tiny blood vessels that appear in the skin and fatty tissues that are also involved in calciphylaxis.

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