Scariest Rare Diseases In The World

Polyglandular Addison's Disease

Polyglandular Addison's disease includes autoimmune adrenal insufficiency, autoimmune hypothyroidism, and type 1 diabetes mellitus. Adrenal insufficiency means the body is not producing enough of two hormones: cortisol and aldosterone. All of these syndromes together take on the name Schmidt syndrome or polyglandular autoimmune syndrome type II. This disease produces overwhelming fatigue, hypoglycemia, weight loss, and changes in the pigment of skin and gums. Patients may also experience dizziness, nausea, vomiting, and salt cravings. This disease often occurs in family clusters and is more deadly in young patients, though with proper treatment, polyglandular Addison’s disease can be managed. When the disease comes on suddenly, it can result in acute adrenal failure.

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