Significant Risk Factors Of Dupuytren's Contracture

Gender

Increased risk factors have been determined and strongly supported in certain genders at different ages. The occurrence of Dupuytren's contracture in men is three times greater then it is in women for most age groups. Around eighty percent of all individuals diagnosed with Dupuytren's contracture are men. Males are also more likely to develop the deformity at a younger age and experience it in a more severe form than women. It is estimated one of every ten men in their fifties are affected by Dupuytren's contracture. When the age increases to men in their seventies, it is estimated this deformity affects one in every four men. Only one in every ten women in their seventh decade of life are affected by Dupuytren's contracture. It is only when the age group exceeds eighty-five years old that the incidence of this deformity is slightly higher in women than it is in men. The exact mechanism of this incidence is not clear, but the androgen receptor expression in the Dupuytren fascia in men has been said to play a role in it.

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