Common Warning Signs Of Vasculitis

Blood Clots

The formation of blood clots can be a symptom indicative of vasculitis. The mechanism behind this occurrence is thought to be associated with the close relationship between the immune system and coagulation processes in the body. Inflammation has a modulating influence on thrombotic responses through several mechanisms. It upregulates procoagulant or stimulates inactive protein synthesis into a clotting enzyme. Inflammation also suppresses fibrinolysis or stops the breakdown process of fibrin in clots no longer needed in the body. Furthermore, inflammatory responses downregulate anticoagulants or naturally occurring proteins in the body responsible for stopping the formation of inappropriate blood clots and inhibiting the extension of existing clots. Because vasculitis is a disease characterized by inflammation of the blood vessels, the inflammatory components are in direct contact with coagulation components. This mechanism may result in the inappropriate formation of clots, the extension of existing clots, and stop the breakdown of clots that are no longer needed. All of these processes can cause blood clots to float freely around the body in the vessels that can become lodged.

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