Symptoms Of Autoimmune Polyendocrine Syndrome

Weakness

Weakness may be experienced in autoimmune polyendocrine syndrome if certain endocrine organs are compromised, namely the parathyroid or the ever-important adrenal glands.

The four small parathyroid glands sit on the outer wings of the butterfly-shaped thyroid gland at the base of your neck. Their purpose is to constantly monitor calcium levels in the bloodstream, a critical element for neuromuscular and neuroelectrical functions in our body. The parathyroid glands quickly detect low calcium levels and release hormones to correct it. Damage to these glands can result in hypocalcemia, which causes tingling, and muscle cramping with weakness.

Patients with APS who develop Addison’s, the adrenal insufficiency, may also experience a different type. Adrenal issues tend to be chronic, and the onset may be slow and insidious. As the disease progresses, the person will produce less of the regulatory hormones needed to control blood pressure, blood sugar, and other important functions. Electrolytes go awry, and blood pressure and glucose levels fall precipitously. Diarrhea and weight loss are common side effects, all contributing to a growing sense of physical loss.