Symptoms Of Alagille Syndrome

Skeletal Abnormalities

Alagille syndrome patients can have skeletal abnormalities of the ribs, vertebrae, and hands. Additionally, the most common findings on radiography are the butterfly-shaped vertebrae of the thorax, which is secondary to the abnormal clefting of the vertebral bodies.

Some of the additional skeletal features affected are the squared proximal portion of the fingers with tapering distal phalanges, and creases of the digital flexion. Other isolated anomalies include shortening of the phalanges, ulna, and radius. This condition is usually identified after an x-ray, but it does not often cause any problems or symptoms. An x-ray can show any other abnormalities that might cause the spine to take an abnormal shape. A possibility also exists to see an increase in the pathological long-bone fractures in the ALGS caused by the cholestasis or intrinsic bone defects.

Continue to reveal more symptoms of Alagille syndrome.