Serious Symptoms Of Hemolytic Uremic Syndrome

Diarrhea

Diarrhea associated with hemolytic uremic syndrome tend to contain blood. Diarrhea or loose stools occur as a complication of infection by certain strains of E. coli bacteria that colonize in the intestines. These E. coli strains include serotypes O157:H7, O103:H2, O145, O113, O111:H8, O121, O26, and O104:H4. A healthy individual's stool is not watery and does not contain any blood because the specialized lining in the large intestine functions to remove excess fluid before it is excreted. The E. coli infections that cause hemolytic uremic syndrome produce a certain toxin in the large intestine called Shiga toxin. The Shiga toxin and other toxins cause severe damage to the specialized tissue that forms the large intestine lining, causing it to lose absorption functionality and rupture blood vessels. This mechanism causes the stool to become loose, watery, and bloody.

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