What Is Amlodipine?

Potential Medication Interactions

Amlodipine is known to interact with other heart medications, including diltiazem. Taking both of these medications could increase the amount of amlodipine in the body, leading to an increase in the potential for side effects. Amlodipine also interacts with antifungal medications such as voriconazole and ketoconazole, and with clarithromycin, an antibiotic. If amlodipine is taken with a cholesterol medication called simvastatin, this might increase the level of simvastatin in the body and produce more side effects. In particular, using amlodipine with medications for erection issues, including sildenafil and avanafil, could increase the patient's risk of developing dangerously low blood pressure. Patients should always let their doctors know about all of the medications and supplements they use to prevent drug interactions.