What Is Ondansetron (Zofran)?

Potential Medication Interactions

Ondansetron is associated with nearly three hundred potential medication interactions. Patients should not use this medication during treatment with apomorphine, and it is known to interact with other serotonin 5-HT3 antagonists as well. Ondansetron can interact with a pain medication called tramadol, and it affects certain types of anticonvulsants, including phenytoin. It can interfere with antidepressants, beta-blockers, antipsychotic medicines, and drugs that reduce heart rate. Patients who take these drugs should ask their doctor whether it is safe for them to use ondansetron or whether they will need to take a different medicine. Since there are so many potential medication interactions that could occur with ondansetron, patients should ask their doctor to review their complete medication list for possible interactions before ondansetron is prescribed. They should also ask their pharmacist to double-check this list for potential issues before dispensing the drug.

Read about when doses of ondansetron need to be taken next.