Overview Of Antidepressants

Medication Interactions

SSRIs should not be taken with tricyclic antidepressants, monoamine oxidase inhibitors, sumatriptan, or other medicines that increase the levels of serotonin in the brain. Taking these medicines together could lead to a dangerous condition known as serotonin syndrome. In addition, patients should avoid using nonsteroidal anti-inflammatories during treatment with SSRIs if at all possible. The use of these medications together is associated with an increased risk of gastrointestinal bleeding. Tricyclic antidepressants are known to interact with carbamazepine, clonidine, cimetidine, and amitriptyline. Patients should inform their healthcare team of all prescription drugs, over-the-counter medicines, herbal supplements, and natural remedies that they are using before any antidepressant is prescribed. Pharmacists will also check for potential drug interactions before dispensing the prescription.