What Are The Side Effects Of Antihistamines?

Moodiness

Moodiness is a recognized potential side effect of antihistamines. While it is most common in children, adults have also reported this symptom. Loratadine is one of the antihistamines most frequently associated with moodiness as a potential side effect, and moodiness has also been noted while on diphenhydramine. Patients have reported experiencing sudden depression while on this medication, and there have also been reports of paranoia, irritability, aggression, and angry outbursts. For loratadine users, the likelihood of experiencing depression may be increased with the use of the twelve-hour tablets designed for extended-release. Some individuals have reported suicidal thoughts while taking antihistamines. Since these mental health changes could be potentially serious, it is important to mention any mood changes to the prescribing physician urgently, especially in the case of sudden depression and suicidal thoughts. The patient should mention the mental changes began with the antihistamine use. It may be necessary to reduce the antihistamine dose, switch to another antihistamine, or switch to a different category of medicine. Patients who take over-the-counter antihistamines should be aware of the risk for mental health changes, and they should also speak to a doctor if these side effects occur while on the medication.

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