Side Effects Of Prednisone

Headaches

Headaches are a side effect that occurs in individuals who take prednisone for an extended period. Headaches are not caused by the mechanism of the medication itself but are more of a complication of the high blood pressure often induced by long-term use of prednisone. Headaches that occur due to high blood pressure caused by prednisone use tend to occur in a bilateral fashion, or on both sides of the head. High blood pressure produces adverse effects on an individual's blood-brain barrier and causes an accumulation of pressure in the brain. Blood can leak from the blood vessels in the brain because of high blood pressure, which produces inflammatory swelling inside of the skull. Because the skull is a bone that is not flexible and cannot expand, the swelling inside of an individual's skull causes the brain tissues to become compressed. The abnormal compression of the brain and surrounding tissues causes nearby nerve fibers to become irritated. These irritated nerves transmit signals of pain responsible for causing the patient to feel pain in their head, neck, and face.

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