Overview Of Spironolactone

Potential Medication Interactions

Spironolactone is known to have potential medication interactions with more than 330 drugs. Serious interactions may occur if spironolactone is taken with other potassium-sparing diuretics or aldosterone receptor antagonists. Other serious interactions could occur if this medicine is used together with aldosterone antagonists, trimethoprim, mitotane, cyclosporin, or tacrolimus. Spironolactone should never be taken with potassium supplements as this could cause serious side effects. Moderate drug interactions have been reported in patients who use spironolactone with some types of ACE inhibitors and certain vasodilators. Moderate interactions may also occur if patients use this medicine with lithium, apomorphine, digoxin, drospirenone, zoledronic acid, moexipril, or tizanidine. Patients should let their doctor know about all of the over-the-counter medicines, prescriptions, vitamins, and supplements they use. They should ask their physician to check their medication list for potential interactions before prescribing spironolactone. They should also ask their pharmacist to double-check for potential medication interactions before dispensing this drug.